Trastornos del desarrollo posnatal temprano del cerebelo en neonatos prematuros: factores cronológicos
Marta Jones
Adriana Mijalovsky, Marina Valencia, Joaquín Drut
Patología
Artículo de Revista
1
2014
52
Patología 2014;52:1-19
1-19
Antecedentes: el impacto negativo que ejerce el nacimiento pretérmino sobre el desarrollo postnatal del cerebelo es un fenómeno ampliamente documentado. Diversos estudios han detallado el cuadro clínico y la topografía y concuerdan en que, cuando esas alteraciones alcanzan Patología Revista latinoamericana 2 Volumen 52, Núm. 1, enero-marzo, 2014 The anatomical and histological evidence that preterm birth is associated with cerebellar injury has been documented for many years.1–4 Those data were later recognized by MRI, through a decrease in the volume of the posterior fossa content in children and adolescents with neurological and neuropsychological disorders and a history of preterm birth.5–11 Moreover, autopsy studies showed that preterm neonates at termequivalent postnatal age had smaller cerebella than those of term neonates, providing histologic and morphometric evidence of alterations in growth and development.12 With the objective of presenting a hypothesis on the impact of preterm birth on cerebellar development, Haldipur and colleagues analyzed quantitatively the changes in the cerebellarcortical layers of preterm neonates that had no infratentorial lesions.13 The conclusion was that the prematurity itself, and perhaps the complications that follow premature birth, modify the growth of that organ. These findings provided evidence on the nature of the cellular mechanisms that operate during the first days of postnatal life, and lay the ground for more investigations that may elucidate the pathogenesis of the small cerebellum in this group of patients. In this report we make particular emphasis on the study of the injured cerebellum. Whether through the effects of immaturity, the abrupt transition cierta magnitud, la vía final común es el así llamado cerebelo pequeño del recién nacido pretérmino. Las etapas iniciales y los mecanismos íntimos de ese proceso, sin embargo, no se conocen con exactitud.
Disorders of early postnatal cerebellar development in preterm neonates: chronological factors
Background. It is well known that preterm birth has a negative impact on the postnatal development of the cerebellum. Several studies have described the clinical features and related topography and have concluded that, when such changes reach a certain magnitude, the final common pathway leads to an undersized cerebellum in preterm neonates. The early stages
Sociedad Latinoamericana de Patología, Asociación Mexicana de Patólogos, Consejo Mexicano de Médicos Anatomopatólogos
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